10-EDAM AND CHEMOTHERAPY FOR NON-SMALL CELL LUNG CANCER

10-EDAM 和化疗治疗非小细胞肺癌

• 批准号: 3849489
• 负责人: JAMES WERNZ
• 金额: --
• 依托单位: NEW YORK UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3849489
• 关键词: aminopterin; clinical trials; combination chemotherapy; drug adverse effect; human subject; human therapy evaluation; lung neoplasms; mitomycins; neoplasm /cancer chemotherapy; vinblastine

The objectives of this protocol are to compare the combination of 10-Ethyl-10-Deaza-Aminopterin (10-EdAM), mitomycin and vinblastin (EMV) with the combination of mitomycin and vinblastine (MV) in the treatment of patients with advanced non-small cell lung cancer and to demonstrate that the two regimens are acceptable in terms of toxicity and to compare their relative toxicity. This is an open-label, multicenter, randomized trial.

本方案的目的是比较以下组合： 10-乙基-10-脱氮氨基蝶呤（10-埃达姆）、丝裂霉素和长春碱（EMV） 与丝裂霉素和长春碱（MV）联合治疗 晚期非小细胞肺癌患者， 这两种方案在毒性方面是可以接受的， 相对毒性 这是一项开放标签、多中心、随机试验。