MECHANISMS OF AUTOANTIBODY PRODUCTION IN SYSTEMIC LUPUS ERYTHEMATOSUS

系统性红斑狼疮自身抗体产生机制

• 批准号: 3849534
• 负责人: WESTLEY H. REEVES
• 金额: --
• 依托单位: ROCKEFELLER UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3849534
• 关键词: Escherichia coli; antibody formation; antigens; autoantibody; autoantigens; autoimmune disorder; cell type; gene expression; genetic manipulation; human subject; molecular cloning; molecular pathology; protein structure function; systemic lupus erythematosus; virus diseases

The basis for autoimmune responses to the Ku (p70/p80), lamin B, and Sm snRNP antigens is being examined by molecular cloning of the relevant autoantigenic proteins, expression in E. coli, and indentification of autoantigenic epitopes by mutagenesis. The functions of these autoantigens are being examined in a variety of different cell types and in viral infections.

自身免疫应答的基础是Ku(p70/p80)、层蛋白B和 SM SnRNP抗原正在通过相关的分子克隆进行检测 自身抗原性蛋白在大肠杆菌中的表达及鉴定 通过诱变获得自身抗原表位。这些组件的功能 自身抗原在各种不同类型的细胞中被检测， 在病毒感染中。