IMMUNOLOGIC MECHANISM OF INHIBITOR ANTIBODY FORMATION IN HEMOPHILIA

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This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. This study is designed to test the hypothesis that inhibitor development in hemophilia is a T-cell dependent immunologic response to coagulation factor replacement therapy. Future plans include the evaluation of genes expressed in peripheral blood mononuclear cells in patients and controls when cultured with factor VIII or IX; and in patient's PBMC's when initially exposed to coagulation factors over time.