SEX STEROID REGULATION OF GONADOTROPIN SECRETION IN AGING MEN

老年男性性类固醇对促性腺激素分泌的调节

• 批准号: 3849073
• 负责人: RANDALL J URBAN
• 金额: --
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3849073
• 关键词: aging; blood chemistry; gonadotropin releasing factor; gonadotropins; hormone regulation /control mechanism; human subject; hypothalamic pituitary axis; intravenous administration; male; secretion; sex hormones; steroid hormone metabolism; steroid hormone receptor

The hypothesis was that hypothalamic-pituitary secretion of gonadotropins in response to sex-steroids is altered in aging men. Healthy older men and young men were studied by infusing sex-steroids and blocking their endogenous receptors. Multiple-parameter deconvolution analysis was used to delineate secretion and clearance parameters of gonadotropins measured through frequent blood samples.

假设下丘脑-垂体分泌促性腺激素 对性类固醇的反应在老年男性中发生了改变。 健康的老年男性和 年轻男性通过注射性类固醇和阻断他们的 内源性受体 采用多参数反褶积分析 描述测量的促性腺激素的分泌和清除参数 通过频繁的血液样本。