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INSULIN MEDIATED EFFECTS ON PROTEIN METABOLISM IN CANCER PATIENTS

INSULIN MEDIATED EFFECTS ON PROTEIN METABOLISM IN CANCER PATIENTS
胰岛素对癌症患者蛋白质代谢的影响
批准号：
3850480
负责人：
JO ANNE BRASEL
金额：
$0.0万
依托单位：
LUNDQUIST INSTITUTE FOR BIOMEDICAL INNOVATION AT HARBOR-UCLA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3850480
关键词：
cachexia cancer complication glucose glucose metabolism human subject insulin leucine neoplasm /cancer nutrition aspect of cancer nutrition related tag protein metabolism radiotracer

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中文摘要
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英文摘要
To study protein breakdown and glucose turnover using infusion of 14C-leucine and 3H-glucose. The effect of insulin infusion on glucose metabolism is studied using euglycemic clamp technique and Bergman Minimal Model. Whether supraphysiologic insulin doses can reverse protein breakdown in cancer patients and its explanation in terms of improved glucose metabolism is to be investigated.
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