THERAPY WITH GROWTH HORMONE ANALOG AND OXANDROLONE IN TURNER'S SYNDROME

生长激素类似物和氧雄龙治疗特纳综合征

• 批准号: 3905882
• 负责人: JO ANNE BRASEL
• 金额: --
• 依托单位: LOS ANGELES COUNTY HARBOR-UCLA MED CTR
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3905882
• 关键词: Turner's syndrome; clinical trials; combination chemotherapy; hormone analog; hormone therapy; human subject; human therapy evaluation; longitudinal human study; oxandrolone; postnatal growth disorder; somatotropin

To evaluate the safety and efficacy of methionyl-hGH alone and in combination with Oxandrolone in alleviation of growth retardation associated with Turner's Syndrome. Patients will be randomly assigned to one of four treatment groups: no treatment (first 12 months only), Oxandrolone alone, methionyl-hGH alone and methionyl- hGH and Oxandrolone. Treatment effects will be evaluated over a period of five years.

评价甲硫氨酰-hGH单独给药和联合给药的安全性和疗效， 与氧甲氢龙联合缓解生长迟缓 与特纳综合征有关。 患者将被随机 分配到四个治疗组之一：无治疗（前12个 月仅），单独的氧甲氢龙，单独的甲硫氨酰-hGH和甲硫氨酰- hGH和氧甲氢龙。 治疗效果将在 为期五年。