2'3' DIDEOXYINOSINE IN PATIENTS WITH AIDS AND AIDS RELATED COMPLEX

23 双脱氧肌苷在艾滋病和艾滋病相关综合症患者中的应用

• 批准号: 3850551
• 负责人: HOWARD LIEBMAN
• 金额: --
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3850551
• 关键词: 2'3' dideoxyinosine; AIDS; AIDS therapy; HIV infections; Herpesviridae disease; antiAIDS agent; clinical trials; cytomegalovirus; drug adverse effect; ganciclovir; human subject; human therapy evaluation; longitudinal human study; pharmacokinetics

This study evaluates the pharmacokinetic toxicity and therapeutic efficacy of escalating doses of dideoxyinosine (ddI) given once a day for the treatment of A and ARC. Amendments have included a pharmacokinetic study of ddI with Gancyclovir in patients with CMV infections and AIDS. Patients are followed for the effects of longterm therapy on ddI.

本研究评价其药代动力学、毒性和治疗效果。 每日一次递增剂量双脱氧肌苷的疗效 用于治疗A和ARC。修正案包括一项 DDI与更昔洛韦在巨细胞病毒患者体内的药代动力学研究 感染和艾滋病。对患者进行长期随访观察其疗效 对DDI的治疗。