ESTROGEN NEGATIVE FEEDBACK IN POSTPARTUM LACTATIONAL AMENORRHEA

产后哺乳期闭经的雌激素负反馈

• 批准号: 3851436
• 负责人: JOANNES D VELDHUIS
• 金额: --
• 依托单位: UNIVERSITY OF VIRGINIA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3851436
• 关键词: amenorrhea; clinical trials; dosage; estrogens; hormone regulation /control mechanism; human subject; hypothalamic pituitary axis; lactation; postpartum

This protocol tests the specific hypothesis that the negative feedback effects of estrogen on the hypothalamo-pituitary axis in postpartum lactational amenorrhea are enhanced. We postulate that the same dose of estrogen administration will produce more marked suppression of LH release basally and in response to GnRH in women with lactational amenorrhea than in non-lactating controls.

该协议测试的具体假设，负反馈 雌激素对产后下丘脑-垂体轴的影响 哺乳期闭经加重。 我们假设相同剂量的 雌激素给药将产生更明显的LH抑制 在哺乳期妇女中基础释放和对GnRH的反应 闭经比非哺乳期对照组。