NATURAL HISTORY OF ARTHRITIS AND RHEUMATISM ON THE GILA RIVER INDIAN COMMUNITY

骨关节病、类风湿性关节炎的发生发展 和强直性脊柱炎是通过临床， 前瞻性地进行放射学和血清学检查， 吉拉河印第安人社区的成年人每两年举行一次 (Pima印第安人）在亚利桑那州，结合流行病学研究， 糖尿病在同一个社区 这次调查的目的是 确定人口中这些疾病的决定因素， 确定易患或改变自然史的因素， 疾病的进展。 宿主因素，如年龄、性别和各种 基因标记包括HLA和Gm，连同各种潜在的 环境决定因素，如肥胖和暴露证据 传染源，正在进行前瞻性研究，以确定 它们与这些疾病的发展之间的关系。 纵向 数据已经收集了25年，代表了一个独特的数据， 准备进行关节炎的流行病学研究。

The development and progression of osteoarthrosis, rheumatoid arthritis and ankylosing spondylitis are being determined by means of clinical, radiographic and serological examinations carried out prospectively at two-yearly intervals among adults of the Gila River Indian Community (Pima Indians) in Arizona, in conjunction with epidemiological studies of diabetes in the same community. The purpose of this investigation is to ascertain the determinants of these diseases in the population, and to identify factors which predispose to or alter the natural history of progression of the disease. Host factors such as age, sex, and various gene markers including HLA and Gm, together with various potential environmental determinants, such as obesity and evidence of exposure to infectious agents, are being investigated prospectively to determine their relationship to the development of these diseases. Longitudinal data have now been collected for 25 years and represent a unique data set for epidemiological studies of arthritis.