CORE--PATHOLOGY

核心--病理学

• 批准号: 3859324
• 负责人: GEORGE E SALE
• 金额: --
• 依托单位: FRED HUTCHINSON CANCER RESEARCH CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3859324
• 关键词: aplastic anemia; biomedical facility; bone marrow transplantation; dyserythropoietic anemia; graft versus host disease; pathology

The Pathology Core provides research support and development for the program project grant as a whole. This work is conducted by four faculty, highly experienced and published in marrow transplantation hematopathology, immunopathology, and infectious disease. Graft-versus- host disease (GVHD) studies are carried out in protocols involving skin, liver and gut studies. The methods and panels of antibodies are being evaluated for studies of the pathogenesis of GVHD with novel antibodies to new cellular subtypes, with new confocal microscopic methods, and with antibodies to cytokines and proliferation markers. The aplastic anemia studies are primarily involved with improving the methodology of frozen sections of bone marrow for immunohistological study of infiltrating cellular subtypes and cytokines in the examination of the pathogenesis of aplastic anemia and in elucidating normal immunoanatomy or immunomorphology of bone marrow which necessarily precedes the analysis of the pathologic states. The infectious studies involve the development and application of new methods of diagnosing viral infections with panels of antibodies, new in situ hybridization methods and newer methods of employing single-stranded probes for the evaluation of pathogenesis and diagnosis of viral infections. Pathology also carries out the histology for the canine studies, myelodysplasia project, all of the biopsies for diagnosis and pathogenetic study of GVHD, and the marrow examinations. The group also carries out all the research autopsies necessary for evaluation of the patients receiving ATG therapy and marrow transplantation who do not survive. Autopsies carried out at other institutions are coordinated and reviewed retrospectively by the staff also.

病理学核心为以下领域提供研究支持和开发： 计划项目拨款作为一个整体。 这项工作是由四位 教师在骨髓移植方面经验丰富并发表过文章 血液病理学、免疫病理学和传染病。 移植物抗- 宿主疾病（GVHD）研究是在涉及皮肤、 肝脏和肠道研究。抗体的方法和组合正在研究中 评估新型抗体 GVHD 发病机制的研究 到新的细胞亚型，用新的共焦显微方法，并与 细胞因子和增殖标记物的抗体。 再生障碍性贫血 研究主要涉及改进冷冻方法 骨髓切片用于浸润的免疫组织学研究 发病机制检查中的细胞亚型和细胞因子 再生障碍性贫血和阐明正常的免疫解剖学或 必须在分析之前进行骨髓免疫形态学检查 的病理状态。 传染性研究涉及发展 病毒感染检测新方法及其应用 抗体、新的原位杂交方法和更新的方法 使用单链探针评估发病机制和 病毒感染的诊断。 病理学还进行组织学检查 对于犬类研究，骨髓增生异常项目，所有的活检 GVHD的诊断和发病机制研究，以及骨髓检查。 该小组还进行了所有必要的尸检研究 接受 ATG 治疗和骨髓评估的患者 移植后不能存活的人。 在其他地方进行尸检 机构由工作人员进行协调和回顾性审查 还。