A NATIONAL STABLE ISOTOPE RESOURCE AT LOS ALAMOS

我们建议继续运作一个国家稳定同位素 资源（SIR）作为洛杉矶更大的ICON计划的一部分 阿拉莫斯国家实验室。 ICONs计划，以 碳（12 C、13 C）、氧（16 O、17 O、18 O）和氮的同位素 (14N，15 N），包括生产大量 CO和NO低温蒸馏分离同位素 气. SIR的主要目标是促进发展 这些同位素的新应用， 生物化学、生物物理学中的问题和 医学 该提案的研究部分建议， 开发高效的特异性标记氨基酸的方法 酸、核酸和酶辅因子。 通过使这些 研究社区可用的材料，资源将 有助于蛋白质和核酸的基础研究 结构，蛋白质-核酸相互作用和结构- 血红素蛋白的功能关系。 该资源将继续开展一系列合作， 和服务活动，旨在扩大稳定 生物医学研究中的同位素，它将有助于 发展稳定同位素标记化合物的商业， 设计有效的程序，将标记的CO和NO转化为 有用的材料。 成为资源中心的特定化合物 将与资源协商选择活动 将提供给外部调查员 在竞争的基础上。 这是最重要的服务之一 的资源。

We propose to continue the operation of a national stable isotope resource (SIR) as part of the larger ICONs program at the Los Alamos National Laboratory. The ICONs program, named for the isotopes of carbon (12C, 13C), oxygen (16O, 17O, 18O), and nitrogen (14N, 15N), includes the production of large quantities of separated isotopes by low temperature distillation of CO and NO gases. The principal goal of the SIR is to promote the development of new application of these isotopes to solving fundamental problems in biochemistry, biophysics and practical problems in medical science. The research component of the proposal suggests development of efficient procedures for specific labeling of amino acids, nucleic acids, and enzyme cofactors. By making these materials available to the research community, the Resource will contribute to fundamental studies of protein and nucleic acid structure, protein-nucleic acid interactions, and structure- function relations in heme proteins. The Resource will continue to carry out a spectrum of collaborative and service activities aimed at broadening the uses for stable isotopes in biomedical research, and it will contribute to the developing commerce in stable isotopically labeled compounds by devising efficient procedures for converting labeled CO and NO to useful materials. The particular compounds which become the focus of Resource activities will be selected in consultation with the Resource's Advisory Committee and will be provided to external investigators on a competitive basis. This is one of the most important services of the Resource.