SCOR IN CORONARY AND VASCULAR DISEASES

冠状动脉和血管疾病中的 SCOR

• 批准号: 3106846
• 负责人: DONALD E STRANDNESS
• 金额: $ 129.76万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-01-01 至 1994-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3106846
• 关键词: artery stenosis; atherosclerosis; atherosclerotic plaque; cardiovascular imaging /visualization; carotid artery; cerebrovascular occlusions; relapse /recurrence

Although research in atherosclerosis has focused on mechanisms of initiation, relatively little attention has been given to the more pressing problems of disease progression and recurrence after vascular reconstruction. There are two major objectives in the SCOR: to develop an understanding of how carotid atherosclerotic plaques enlarge and at a certain point become the cause of thromboembolic events; and to explore various aspects of the reparative response and the recurrence of lumenal narrowing after endarterectomy. Four of the projects will examine ultrasound characteristics of advanced atherosclerotic carotid and femoral lesions and endarterectomy-induced intimal thickening. These will be correlated with clinical symptoms and with the pathological characteristics of the excised surgical specimens. In addition, these lesions will be examined by in situ hybridization and Northern analysis for the expression of specific genes important for smooth muscle growth. Magnetic resonance imaging studies will be undertaken in vitro and in vivo model systems to develop better methods for the morphological and biochemical characterization of the human plaque. At the same time, animal models of disease progression and recurrent stenosis will be developed to define factors regulating smooth muscle proliferation and endothelial regeneration. In addition to an Administrative Core, the SCOR will have Morphology an Image Analysis Cores to provide histological, immunocytological, and image procession support for the individual projects. The proposed studies will make use of a wide range of clinical basic research approaches, including ultrasound, MRI, light and electron microscopy, in situ hybridization, Norther analysis, analysis of cell cycle kinetics and modern approaches to growth factor biochemistry.

尽管动脉粥样硬化的研究主要集中在 在开始时，相对较少关注更紧迫的问题， 血管内支架植入后的疾病进展和复发问题 重建 该委员会有两个主要目标： 了解颈动脉粥样硬化斑块如何扩大， 某些点成为血栓栓塞事件的原因;并探讨 修复反应和管腔复发的各个方面 动脉内膜切除术后狭窄。 其中四个项目将审查 晚期颈动脉和股动脉粥样硬化的超声特征 病变和动脉内膜切除术诱导的内膜增厚。 这些将是 与临床症状及病理特征相关 切除的手术标本 此外，这些病变将 通过原位杂交和北方分析检测表达 平滑肌生长的重要基因 磁共振成像研究将在体外和体内进行 模型系统，以开发更好的方法， 人斑块的生化表征。 与此同时，动物 将开发疾病进展和复发性狭窄的模型， 确定调节平滑肌增殖和内皮细胞增殖的因子 再生 除了行政核心外，SCOR还将拥有 形态学和 图像分析核心提供组织学， 免疫细胞学和图像处理支持的个人 项目 拟议的研究将利用广泛的临床基础 研究方法，包括超声波，MRI，光和电子 显微镜，原位杂交，Norther分析，细胞周期分析 动力学和生长因子生物化学的现代方法。