STRUCTURE AND FUNCTION OF FETAL PROTEIN C (PC)

胎儿蛋白 C (PC) 的结构和功能

• 批准号: 3863402
• 负责人: MARILYN J MANCO-JOHNSON
• 金额: --
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3863402
• 关键词: anticoagulants; embryo /fetus protein; hemostasis; human subject; infant human (0-1 year); protein C; protein structure function; thrombosis

The protein c anticoagulant is important in the regulation of hemostasis and thrombosis. Previous work performed by our group indicates that the fetal PC molecule may be dysfunctional compared to the adult molecule and thereby contribute to the increased incidence of thrombosis seen in the sick preterm and term infant. We propose to investigate and compare the molecular, structural, anticoagulant, and profibrinolytic properties of fetal and adult PC in order to learn more about the fetal PC system.

蛋白c抗凝剂在止血调节中起重要作用 和血栓形成。我们小组以前的工作表明， 胎儿PC分子与成人分子相比可能功能失调， 从而增加了血栓形成的发生率， 患病早产儿和足月儿。我们建议调查和比较 分子、结构、抗凝血和纤溶原特性 胎儿和成人PC，以了解更多关于胎儿PC系统。