Defining key determinants of HLA mediated T cell tolerance and autoimmunity

定义 HLA 介导的 T 细胞耐受和自身免疫的关键决定因素

• 批准号: nhmrc : GNT1162384
• 金额: $ 139.2万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-key-determinants-tolerance-autoimmunity/1379225
• 关键词: Defining; key; determinants; HLA; mediated

When the immune system malfunctions it can cause the body to lose tolerance one or more of its own proteins, leading to autoimmune diseases that affect more than 5% of the population. This project uses autoimmune kidney disease to study why we lose tolerance to ourselves. Understanding this process is not only fundamental to defining the basis of autoimmune diseases but also a key step in the development of more effective, more targeted and less toxic therapies in the future.

当免疫系统出现故障时，可能会导致身体对自身的一种或多种蛋白质失去耐受性，导致影响超过5%人口的自身免疫性疾病。这个项目使用自身免疫性肾脏疾病来研究为什么我们会对自己失去耐受性。了解这一过程不仅是确定自身免疫性疾病基础的基础，也是未来开发更有效、更有针对性和毒性更低的疗法的关键一步。