DETERMINATION OF OPTIMAL TREATMENT OF N5,N10 METHYLENE TETRAHYDROFOLATE

N5,N10亚甲基四氢叶酸最佳处理方法的确定

• 批准号: 3863906
• 负责人: JOHN A PHILLIPS
• 金额: --
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3863906
• 关键词: 5,10 methylenetetrahydrofolate; betaine compound; carnitine; clinical trials; dosage; folate; human subject; human therapy evaluation; methionine

A patient is being monitored monthly to determine the optimal dose and interval of betaine administration, minimal effective dose of folate and necessity of supplementation with carnitine and/or methionine to correct biochemical and clinical abnormalities.

每月监测患者以确定最佳剂量， 甜菜碱给药间隔，最小有效剂量的叶酸， 补充肉毒碱和/或蛋氨酸以纠正 生化和临床异常。