DEVELOPMENT AND MAINTENANCE OF A LONG-TERM COLONY

该合同的目标是提供一群杂交大鼠 年龄范围从1到36个月， 调查人员在美国各地的行为， 老年学研究 与大多数其他生物医学 需要啮齿动物模型的学科，老年学研究涉及 代表完整寿命的啮齿动物模型。 这些动物必须 在遗传学和微生物学上具有特征， 最严格的条件，以尽量减少环境和/或 疾病变量，以便人们可以区分由于年龄的差异， 在研究结束时的环境或疾病。 该特定 合同将提供近交的布朗挪威（BN）大鼠和 近交Fischer 344（F344）雌性的Fl杂种与BN交配。

The objective of this contract is to provide a colony of hybrid rats that range in age from 1 to 36 months that will be available to investigators throughout the United States for the conduct of gerontological research. As opposed to most other biomedical disciplines requiring rodent models, gerontologic research involves rodent models representative of complete lifespan. These animals must be characterized genetically and microbiologically an maintained under the strictest of conditions in order to minimize environmental and/or disease variables so that one can differentiate differences due to age, environment or disease at the conclusion of studies. This particular contract will provide a supply of inbred Brown Norway (BN) rats and the Fl hybrid of the inbred Fischer 344 (F344) female mated to the BN.