EFFECTS OF METHIONINE-FREE GROWTH HORMONE TREATMENT ON NITROGEN RETENTION

无蛋氨酸生长激素处理对氮保留的影响

• 批准号: 3866934
• 负责人: DOUGLAS W WILMORE
• 金额: --
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3866934
• 关键词: gastric fistula; gastrointestinal disorder; hormone regulation /control mechanism; human subject; human therapy evaluation; nitrogen balance; nutrition related tag; parenteral feedings; protein metabolism; somatotropin

Growth hormone enhances protein synthesis and improves nitrogen balance when administered with adequate nutrition. In this study, patients requiring long-term nutritional support (>3 weeks) because of fistulas or gastrointestinal disease will be randomized into two groups. One group will receive placebo injections and the second group will receive growth hormone (10mg.daily). The effects on nitrogen and mineral economy will be compared.

生长激素促进蛋白质合成，改善氮平衡 当给予足够的营养时。 在这项研究中，患者 因瘘管需要长期营养支持（>3周），或 胃肠道疾病将被随机分为两组。 一组 将接受安慰剂注射，第二组将接受生长 激素10 mg/d。 对氮和矿物经济的影响将是 比较了