TRAUMA: REGULATORS AND MODULATORS OF THE CATABOLIC STAT

创伤：分解代谢状态的调节剂和调节剂

• 批准号: 3106087
• 负责人: DOUGLAS W WILMORE
• 金额: $ 81.82万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1985
• 资助国家: 美国
• 起止时间: 1985-09-01 至 1986-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3106087
• 关键词: muscle metabolism; proteolysis; trauma

(1) To determine the regulation of amino acid release from skeletal muscle and identify the altered control mechanisms following stress and trauma. To determine the influence of ketone bodies, branched chain amino acids, and various hormones on these mechanisms. (2) To characterize hormone fuel fluxes and their control across skeletal muscle bed in various states. To determine the effect of nutrients and hormones on these substrate fluxes. (3) To determine the effects of parenteral nutrition on fuel oxidation, storage and protein synthesis in critically ill traumatized patients and then elucidate the mechanisms which regulate these processes. To determine the effect of euglycemia and hyperglycemia during glucose administration on hepatic glucose and fat balance, organ distribution and metabolic handling of other nutrients administered with the glucose infusion. (4) To determine the optimal timing of oral and intravenous nutrient administration and the influence of exercise to maximize weight gain and nitrogen balance. (5) To determine the effects of maximal nutritional support on impaired cellular function noted in patients after surgical operations and trauma and characterize the site of production of the circulating immunosuppressive factors. Molecular mechanisms will be determined in myoblast tissue cultures and analysis of biopsies taken from the hindlimb of the dog. Fuel flux studies will be done in the dog and injured patients. The effect of exercise and timing of feeding will be determined in the squirrel monkey. The effect of nutritional support on immunity will be performed in patients. Localization of the production of circulating immunosuppressive factors will be performed in sheep.

(1)确定骨骼肌氨基酸释放的调节 并确定压力和创伤后改变的控制机制。 为了确定酮体、支链氨基酸、 以及各种激素的作用。 (2)来描述激素燃料 通量和它们在各种状态下穿过骨骼肌床的控制。 到 确定营养物质和激素对这些底物通量的影响。 (3)为了确定肠外营养对燃料氧化的影响， 储存和蛋白质合成在危重创伤患者， 然后阐明调节这些过程的机制。 以确定 葡萄糖给药期间的血糖和高血糖对 肝脏葡萄糖和脂肪平衡、器官分布和代谢处理 与葡萄糖输注一起给予的其他营养素。 (4)到 确定口服和静脉营养的最佳时间 管理和运动的影响，以最大限度地增加体重， 氮平衡 (5)为了确定最大营养的影响， 支持手术后患者的受损细胞功能 手术和创伤，并描述生产的网站， 循环免疫抑制因子。 分子机制将是 在成肌细胞组织培养物中测定， 狗的后肢 燃料通量研究将在犬中进行， 受伤的病人。 运动和喂食时间的影响将是 在松鼠猴身上决定的。 营养支持对 将在患者中进行免疫。 本地化生产 循环免疫抑制因子将在绵羊中进行。