Immune defense, disease and damage control in the wild

野外免疫防御、疾病和损害控制

• 批准号: DP150103595
• 负责人: Dr Anne-Marie Peters
• 金额: $ 24.5万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Projects
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-09-16 至 2019-12-31
• 项目状态: 已结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DP150103595
• 关键词: Immune; defense; disease; damage; control

Immune defences are vital for resistance against infections, but are an overlooked component of disease dynamics in the wild. The project aims to use a model system of long-term studied wild birds to investigate causes of individual variation in innate immunity, the critical first-line-of-defence against new infections. The results may show how immune dynamics are linked to disease, aging, reproduction and longevity and to what extent this is environmentally-determined or inherited (its adaptive potential). The outcomes could provide broadly generalizable insights into interactions between the immune system and the environment, and may identify risk factors for vulnerability to novel infectious diseases.

免疫防御对于抵抗感染至关重要，但在野外的疾病动态中却是一个被忽视的组成部分。该项目旨在使用长期研究野生鸟类的模型系统来调查先天免疫个体差异的原因，先天免疫是抵御新感染的关键第一道防线。结果可能会显示免疫动态如何与疾病、衰老、生殖和寿命联系在一起，以及这在多大程度上是环境决定的或遗传的(其适应潜力)。这些结果可以为免疫系统和环境之间的相互作用提供广泛的概括性见解，并可能确定易受新传染病影响的风险因素。