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PEPTIDE SYNTHESIZER AMINO ACID ANALYZER

PEPTIDE SYNTHESIZER AMINO ACID ANALYZER
肽合成仪 氨基酸分析仪
批准号:
3521134
负责人:
MICHAEL B DOUGHTY
金额:
$6.3万
依托单位国家:
美国
项目类别:
财政年份:
1991
资助国家:
美国
项目状态:
已结题
起止时间:
1991-05-22 至 1992-05-21

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中文摘要
翻译
这项拨款建议建立一个肽合成、纯化和
英文摘要
This grant proposes to establish a peptide synthesis, purification, and analysis system at the University of Kansas. In the last few years the Departments of Biochemistry, Chemistry, Medicinal Chemistry, Microbiology, and Pharmaceutical Chemistry have demonstrated an increasing demand for the synthesis of peptides in order to explore enzyme catalytic mechanisms, for the generation and purification of antibodies, for examining the stability and transport of peptide and protein pharmaceuticals, and for detailing the structure and activities of neuropeptides. To meet this growing demand, we propose to establish a peptide laboratory as part of the University's Biochemical Research Service Laboratory, under the direction of Dr. Charles Decedue. The requested equipment include: an Applied Biosystems Model 431A peptide synthesis system with single reaction vessel and resin sampler, a Peninsula Type 4B HF reaction apparatus with manometer, a Waters 625LC analytical HPLC, a Waters PicoTag amino acid analysis system, and a Waters DeltaPrep 3000 preparative HPLC. The PI will oversee the design and development of synthetic and purification strategies, as well as the training of laboratory personnel, and Dr. C Decedue will oversee day to day operations of the instruments and routine maintenance. The facility will be designed for complete service, including the design of target peptides, if necessary, or partial service for researchers requesting involvement in the synthesis or purification stages. The center will also accommodate special synthetic procedures, the coupling of non-natural or synthetic amino acids, and the fragment condensation of peptides using either t-boc or f-moc chemistry. The goal of this service will be to enhance peptide- related biomedical research at the University by providing timely turnaround and a purified product at cost.
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Combined Substrate Polymerase Inhibitors
  • 批准号:
    6701914
  • 项目类别:
  • 资助金额:
    $12.21万
  • 财政年份:
    2004
  • 负责人:
    MICHAEL B DOUGHTY
  • 依托单位:
Combined Substrate Polymerase Inhibitors
Combined Substrate Polymerase Inhibitors
  • 批准号:
    7193355
  • 项目类别:
  • 资助金额:
    $19.46万
  • 财政年份:
    2003
  • 负责人:
    MICHAEL B DOUGHTY
  • 依托单位:
NPY PEPTIDOMIMETICS--DESIGN, SYNTHESIS AND EVALUATION
  • 批准号:
    2655482
  • 项目类别:
  • 资助金额:
    $18.88万
  • 财政年份:
    1995
  • 负责人:
    MICHAEL B DOUGHTY
  • 依托单位:
海外基金