Bacterial membrane remodelling and the interaction with peptides

细菌膜重塑及其与肽的相互作用

• 批准号: DE230100356
• 负责人: Dr Meiling Han
• 金额: $ 31.71万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Discovery Early Career Researcher Award
• 财政年份: 2023
• 资助国家: 澳大利亚
• 起止时间: 2023-01-01 至 2026-03-18
• 项目状态: 未结题
• 来源: https://dataportal.arc.gov.au/RGS/Web/Grants/DE230100356
• 关键词: Bacterial; membrane; remodelling; interaction; peptides

This project aims to elucidate the fundamental mechanism of lipid remodelling in Gram-negative outer membrane, which is critical both in preventing noxious compounds and evading host immune defence. For the first time, the complex interplays between bacterial cellular metabolism and membrane remodelling will be defined through systems pharmacology, and the precise membrane-peptide interaction will be examined by computational and biophysical approaches. Novel knowledge will be generated to improve our understanding on how bacteria remodel their outer membrane in response to environmental stress. This will benefit the future design of much-needed antimicrobial strategies including products and technologies to target bacterial membrane.

本项目旨在阐明革兰氏阴性菌外膜脂质重塑的基本机制，这对于防止有毒化合物和逃避宿主免疫防御至关重要。这是第一次，细菌细胞代谢和膜重塑之间的复杂相互作用将通过系统药理学定义，精确的膜肽相互作用将通过计算和生物物理方法进行检查。将产生新的知识，以提高我们对细菌如何重塑其外膜以应对环境压力的理解。这将有利于未来设计急需的抗菌策略，包括针对细菌膜的产品和技术。