ACQUISTION OF A VAX COMPUTER SYSTEM

加州大学洛杉矶分校的生命科学系在文学院和 科学和健康科学中心在世界上名列前茅。 国家，并且在NIH资助的分子生物学研究中有一个主要的优势， 生物学 这些多种多样的生物医学之间的联系 研究项目是详细的计算分析的要求， 核酸和蛋白质序列。 1985年，VAX 11/750小型计算机被 通过NIH BRS多用户设备资助购买， 建立了分析设施。 该设施包括VAX 11/750，通过Decnet和以太网连接到所有主要计算机 12台IBM PS2-50微型计算机通过直接线路连接到 VAX。 除了带打印机的微型计算机外，该设施还有一个 光学扫描仪（Datacopy）、三台HP绘图仪、两台HP激光打印机、一台 IBI数字化仪用于顺序阅读，以及计算机化密度计。 几个主要的序列分析软件包在VAX上运行， 除了所有的主要序列数据库与适当的 搜索软件 该设施的使用量已从最初的16 用户到来自69个实验室的196个用户，以及当前的VAX 11/750 计算机显然已不足以支持这项大型研究 社区 因此，我们提交了升级VAX的建议 为了保持最先进的研究水平， 在加州大学洛杉矶分校的生命科学能力。

The departments of Life Sciences at UCLA in the College of Letters and Sciences and in the Center for Health Sciences rank among the best in the nation, and there is a major strength in NIH-funded research in molecular biology. The connecting link between these multiple diverse biomedical research projects is the requirement for detailed computational analysis of nucleic acid and protein sequences. In 1985 a VAX 11/750 minicomputer was purchased through an NIH BRS multiuser equipment grant, and a sequence analysis facility was established. This facility consists of the VAX 11/750, which is connected by Decnet and Ethernet to all the major computer networks, and 12 IBM PS2-50 microcomputers connected by direct lines to the VAX. In addition to microcomputers with printers, the facility has an optical scanner (Datacopy), three HP plotters, two HP lasers printers, an IBI digitizer for reading in sequences, and a computerized densitometer. Several major sequence analysis packages are running on the VAX, in addition to all the major sequence databases together with the appropriate search software. The usage of this facility has grown from an original 16 users to 196 users from 69 laboratories, and the current VAX 11/750 computer is clearly no longer adequate for supporting this large research community. We are therefore submitting this proposal for upgrading the VAX computer for this facility in order to maintain state of the art research capabilities in Life Sciences at UCLA.