THEORETICAL STUDIES OF DYNAMICAL PROCESSES IN CHEMICAL PHYSICS AND BIOPHYSICS

化学物理和生物物理动力学过程的理论研究

• 批准号: 3875847
• 负责人: R ZWANZIG
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3875847
• 关键词: biophysics; chemical binding; diffusion; fluidity; ligands; molecular dynamics; physical chemical interaction; protein structure function; receptor binding

The general focus of research has been on rate processes in disordered systems. One investigation dealt with diffusion in a disordered medium, and in particular with the effects of time- and space-dependent fluctuations in the diffusion coefficient. Ibis is potentially useful in understanding chemical kinetics in biochemical processes in cells. In a second investigation, a new treatment has been made of Berg and Purcell's theory of diffusion controlled ligand binding to receptors randomly distributed on the surface of a cell. Aside from improving on our understanding of their theory, the new treatment makes a modest improvement on its accuracy. In a third area, a major review has been written about theoretical methods that have been invented to treat kinetic processes where rate constants can fluctuate in time (dynamical disorder). Since there are many areas of chemical physics and biophysics in which dynamical disorder is important (e.g. protein dynamics or fluorescence depolarization), a unified treatment of the various methods that have been proposed is expected to be generally useful.

研究的一般焦点一直是无序的速率过程 系统.一项研究涉及无序介质中的扩散， 特别是与时间和空间有关的波动的影响， 扩散系数。Ibis可能有助于了解 细胞中生化过程的化学动力学。在第二 本文对贝格和珀塞尔理论作了新的处理 扩散控制的配体与随机分布在 细胞的表面。除了提高我们对他们的理解， 理论上，新治疗方法的准确性略有提高。中 第三个方面，对理论方法进行了一次重要的回顾， 已经被发明来处理动力学过程，其中速率常数可以 动态无序（dynamic disorder）由于有许多领域， 化学物理学和生物物理学，其中动力学无序是重要的 (e.g.蛋白质动力学或荧光去极化），统一的治疗 在已经提出的各种方法中， 有用的.