Defining phenotypic variation in the gut-to-brain signalling responses to hexose sugars.

肥胖的发病率和饮用含糖饮料之间有着密切的联系。拟议的研究将描述(i)糖从肠道向大脑发出信号以调节食物摄入的途径，（ii）肠道肽在该信号中的作用，以及（iii）这些反应中个体之间的差异。这一信息将提供重要的见解，解释为什么有些人在摄入高糖饮食后更容易发胖。

There is a strong link between the incidence of obesity and consumption of sweetened beverages. The proposed studies will characterise (i) the pathway(s) by which sugars signal from the gut to the brain to regulate food intake, (ii) the role of gut peptides in this signalling, and (iii) the variations between individuals in these responses. This information will provide important insights as to why some individuals are more likely to gain weight in response to exposure to diets high in sugar.