Defining phenotypic variation in the gut-to-brain signalling responses to hexose sugars.

定义肠道到大脑对己糖的信号反应的表型变异。

• 批准号: nhmrc : 519349
• 负责人: Dr Tanya Little
• 金额: $ 21.44万
• 依托单位: The University of Adelaide
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-phenotypic-variation-hexose-sugars/115706
• 关键词: Defining; phenotypic; variation; gut; brain

There is a strong link between the incidence of obesity and consumption of sweetened beverages. The proposed studies will characterise (i) the pathway(s) by which sugars signal from the gut to the brain to regulate food intake, (ii) the role of gut peptides in this signalling, and (iii) the variations between individuals in these responses. This information will provide important insights as to why some individuals are more likely to gain weight in response to exposure to diets high in sugar.

肥胖症的发生率与饮用含糖饮料之间有很强的联系。拟议中的研究将描述(I)糖从肠道向大脑发出信号以调节食物摄入量的途径(S)，(Ii)肠肽在这一信号中的作用，以及(Iii)个体之间在这些反应中的差异。这些信息将提供重要的见解，解释为什么一些人更有可能因接触高糖饮食而增加体重。