CENTER FOR POPULATION RESEARCH

拟议的研究计划是设立一个人口研究中心 (P30)人类生殖和生殖生物学实验室 （LHRRB），以促进知识的获取，最终可以 用于控制生育率和减少生殖 疾病和残疾。 这项生物医学人口研究将是 以协调的跨学科方式进行，包括 卵巢，睾丸， 神经内分泌、胚泡和早期胚胎功能。 这项工作是 主要在来自哺乳动物（包括人类）的材料中进行 适用于人类生物学。 例如，这项研究涉及： 颗粒细胞质膜的结构和分子变化， 在卵母细胞减数分裂的启动和维持中，肌动蛋白和 细胞分裂中的肌球蛋白，决定核形状和功能的因素 精子，睾丸中的促有丝分裂肽，胚泡液的控制， 肿胀，脑、卵巢和睾丸中的类固醇代谢，支持细胞 功能，睾丸和卵巢的促性腺营养控制，生殖和 性行为，DNA功能中的分子事件， 顶体反应和精子表面形貌。 共享的核 人口研究中心拨款资助的设施和服务 和其他LHRRB资源提供电子显微镜，组织学， 摄影、放射免疫测定、计算机服务、电子探针、质谱 光谱学，高压液相色谱，氨基酸分析， 动物设施，中央管理，研讨会计划，中央 洗玻璃和机械车间 共享的核心服务和设施 提供研究协调，促进跨学科合作， 并提高质量控制、生产率和成本效益。

The proposed research plan is to operate a Center for Population Research (P30) within The Laboratory of Human Reproduction and Reproductive Biology (LHRRB) to foster the acquisition of knowledge that can ultimately be applied to the control of fertility and the reduction of reproductive disease and disability. This biomedical population research will be conducted in a coordinated INTERDISCIPLINARY manner including the biomedical, physiological and morphological aspects of ovarian, testicular, neuroendocrine, blastocyst and early embryonic function. This work is carried out largely in material derived from mammals (including the human) applicable to human biology. This research involves for example: STRUCTURAL and MOLECULAR changes in the plasma membrane of granulosa cells, initiation and maintenance of MEIOSIS in the oocyte, the role of ACTIN an MYOSIN in CYTOKINESIS, factors determining the nuclear shape and function of SPERM, mitogenic peptides in the testis, control of blastocyst fluid and swelling, steroid metabolism in the brain, ovary and testis, sertoli cell function, CONADOTROPHIC CONTROL of the testis and ovary, reproductive and SEXUAL BEHAVIOR, molecular events in DNA FUNCTION, membrane changes in the ACROSOME REACTION and sperm cell surface topography. The shared CORE FACILITIES and services funded by the Center for Population Research grant and other LHRRB resources provide electron microscopy, histology, photography, radioimmunoassay, computer services, electron probe, mass spectroscopy, high pressure liquid chromatography, amino acid analysis, animal facilities, central administration, a seminar program, central glasswashing, and a machine shop. The shared core services and facilities provide coordination of research, fosters interdisciplinary collaboration, and enhances QUALITY CONTROL, PRODUCTIVITY and COST EFFECTIVENESS.