ICRF-187 对高血压中表柔比星毒性的影响-猫眼课题宝

ICRF-187 对高血压中表柔比星毒性的影响

批准号：

3879024

负责人：

V J FERRENS

金额：

$0.0万

依托单位：

NATIONAL HEART, LUNG, AND BLOOD INSTITUTE

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/3879024

关键词：

antihypertensive agents cardiotonic agents cardiotoxin doxorubicin drug adverse effect kidney disorder myocardium disorder renal toxin spontaneous hypertensive rat

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英文摘要

Spontaneously hypertensive rats treated with cumulative doses of 18 mg/kg of epirubicin developed severe cardiomyopathy and severe nephropathy. Pretreatment with ICRF-187 resulted in marked reduction in the severity of the cardiomyopathy and in moderate reduction in the severity of the nephropathy. These results were similar to those previously obtained with respect to the toxic effects produced by doxorubicin in hypertensive rats.

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