ALVEOLAR MACROPHAGES FROM EXPOSURE TO INORGANIC DUSTS

经支气管肺泡灌洗回收人肺泡巨噬细胞 通过光学显微镜对长期接触无机粉尘的人进行评估 并通过透射和扫描电子显微镜观察。肺泡巨噬细胞 接触粉尘的人含有更高比例的颗粒物 比正常未接触过的受试者更多。此外，其表面 这些巨噬细胞表现出活化的特征，包括增加 褶皱、丝状足、吞饮小泡、亚质膜的数量 巨噬细胞-巨噬细胞的线性密度和频率增加 巨噬细胞与淋巴细胞的相互作用。这些变化，它们与 随着溶酶体数量的增加，强调重要的吞噬细胞 巨噬细胞在防御下呼吸道中的作用。

Alveolar macrophages recovered by bronchoalveolar lavage from individuals chronically exposed to inorganic dust were evaluated by light microscopy and by transmission and scanning electron microscopy. Alveolar macrophages from dust-exposed individuals contained a higher proportion of particles than did those of normal unexposed subjects. In addition, the surfaces of these macrophages showed features of activation, including increased numbers of rufflings, filopodia, pinocytotic vesicles, subplasmalemmal linear densities, and increased frequency of macrophage-macrophage and macrophage-lymphocyte interactions. These changes, which were associated with increased numbers of lysosomes, emphasize the important phagocytic role of macrophages in defending the lower respiratory tract.