NMDA RECEPTORS AND DEVELOPMENTAL PLASTICITY

NMDA 受体与发育可塑性

• 批准号: 3878761
• 负责人: CARL COTMAN
• 金额: --
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3878761
• 关键词: animal developmental psychology; aspartate; autoradiography; central neural pathway /tract; developmental neurobiology; early experience; hippocampus; inhibitor /antagonist; inositol phosphates; laboratory rat; lateral olfactory area; neuroanatomy; neurotransmitter receptor; olfactory lobe; olfactory stimulus; second messengers

The goal of this project is to study the NMDA receptor in development and developmental plasticity. We will examine the development of the NMDA receptor complex in olfactory and hippocampal circuits in relationship to the critical periods for olfactory learning. We will also pursue studies on the action of NMDA antagonists in early olfactory glomerular plasticity. This will consist of identifying the minimal period of administration, the use of newly developed and highly specific analogues, and the direct administration of compounds into the brain. Collaborative projects are proposed to investigate the relationship between NMDA receptor activation, other neurotransmitter systems, and early learning.

这个项目的目标是研究发育中的NMDA受体。 和发育可塑性。我们将研究 NMDA受体复合体在大鼠嗅觉和海马区的分布 与嗅觉学习的关键时期的关系。我们会 也继续研究NMDA拮抗剂在早期嗅觉中的作用 肾小球可塑性。这将包括识别最小的 在管理期间，使用新开发的和高度具体的 类似物，以及化合物直接进入大脑。 提出了合作项目来调查这一关系 在NMDA受体激活、其他神经递质系统和 早期学习。