NMDA 受体与发育可塑性-猫眼课题宝

NMDA 受体与发育可塑性

批准号：

3878761

负责人：

CARL COTMAN

金额：

$0.0万

依托单位：

UNIVERSITY OF CALIFORNIA-IRVINE

依托单位国家：

美国

项目类别：

财政年份：

资助国家：

美国

项目状态：

未结题

起止时间：

至

来源：

https://reporter.nih.gov/project-details/3878761

关键词：

animal developmental psychology aspartate autoradiography central neural pathway /tract developmental neurobiology early experience hippocampus inhibitor /antagonist inositol phosphates laboratory rat lateral olfactory area neuroanatomy neurotransmitter receptor olfactory lobe olfactory stimulus second messengers

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英文摘要

The goal of this project is to study the NMDA receptor in development and developmental plasticity. We will examine the development of the NMDA receptor complex in olfactory and hippocampal circuits in relationship to the critical periods for olfactory learning. We will also pursue studies on the action of NMDA antagonists in early olfactory glomerular plasticity. This will consist of identifying the minimal period of administration, the use of newly developed and highly specific analogues, and the direct administration of compounds into the brain. Collaborative projects are proposed to investigate the relationship between NMDA receptor activation, other neurotransmitter systems, and early learning.

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