Defining the role of VEGF and vascular formation in craniofacial development

定义 VEGF 和血管形成在颅面发育中的作用

• 批准号: nhmrc : 1067848
• 负责人: Dr Quenten Schwarz
• 金额: $ 42.44万
• 依托单位: University of South Australia
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/defining-role-vegf-craniofacial-development/454601
• 关键词: Defining; role; VEGF; vascular; formation

Aberrant neural crest cell development gives rise to common congenital malformations such as cleft lip and/or palate and cardiac outflow tract defects that effect over 1% of all births. As the aetiology of these disorders are largely unknown it is critical to understand the cell and molecular mechanisms coordinating NCC development such that alternative therapies may be devised to target the underlying pathological defects and to provide definitive diagnostic / prognostic tools.

异常的神经嵴细胞发育导致常见的先天性畸形，如唇裂和/或腭裂和心脏流出道缺陷，影响超过1%的新生儿。由于这些疾病的病因在很大程度上是未知的，因此了解协调NCC发展的细胞和分子机制至关重要，这样可以设计替代疗法来针对潜在的病理缺陷，并提供明确的诊断/预后工具。