ZIDOVUDINE WITH PROBENECID--EFFECTS OF PROBENECID ON ZIDOVUDINE

齐多夫定与丙磺舒--丙磺舒对齐多夫定的影响

• 批准号: 3886804
• 负责人: BRENT G PETTY
• 金额: --
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3886804
• 关键词: antiAIDS agent; clinical trials; combination chemotherapy; drug administration rate /duration; drug metabolism; drug tolerance; human subject; human therapy evaluation; immunopathology chemotherapy; pharmacokinetics; probenecid; zidovudine

This study was a four-week open label pharmacokinetic and tolerance study designed to investigate the effects of repetitive dosing of probenecid on the area under the serum concentration time curve of zidovudine and the four-week tolerance of probenecid given in combination with zidovudine.

本研究是一项为期 4 周的开放标签药代动力学和耐受性研究 旨在研究丙磺舒重复给药的影响 齐多夫定血清浓度时间曲线下面积 丙磺舒与齐多夫定联合给药的耐受性为 4 周。