KIDNEY AND UROLOGICAL RESEARCH CENTERS

肾脏和泌尿科研究中心

• 批准号: 3105862
• 负责人: AHMAD ELBADAWI
• 金额: $ 61.91万
• 依托单位: UPSTATE MEDICAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-09-01 至 1992-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3105862
• 关键词: cats; urinary tract obstruction

One of the current main concerns of the discipline of clinical urology is the accurate diagnosis and optimal treatment of obstructive uropathy. It is well known that urethral obstruction can lead to ureteral dysfunction, and eventually to deterioration of renal function. Yet, precise knowledge of the mechanisms by which the commonest cause of clinical obstructive uropathy (namely, vesical outlet obstruction) alters vesical, ureteral and ultimately renal function is still lacking. The specific aim of this proposal is to define the pathogenetic mechanisms of vesical, ureteral and renal dysfunctions in obstructive uropathy, by integrated functional, morphologic and biochemical studies. In this proposal, a valid quantifiable cat model of urethral obstruction will be created. Two models are planned in this proposal: one of a high-grade, and another of a milder and more gradually developing "obstruction". Once obstruction has developed and been characterized urodynamically in both models, subsequent study of the neuromuscular structure, the in vitro contractility, autonomic receptor densities, pharmacologic responses, and biochemical profile of the detrusor and ureteral muscularis will be correlated with their in vivo function, to define the mechanism(s) of obstructive vesical and ureteral dysfunctions. Subsequently, the relation of a certain degree of infravesical obstruction to renal functional parameters - including renal blood flow, tubular function, renal secretory products and glomerular filtration - will be defined. Morphologic changes in the renal parenchyma will also be defined and correlated with functional parameters.

临床医学学科目前主要关注的问题之一是 泌尿外科是准确的诊断和最佳的治疗方法， 梗阻性尿路病 众所周知，尿道梗阻 会导致输尿管功能障碍，最终恶化 肾功能 然而，精确的机制知识， 这是临床阻塞性尿路病最常见的原因， （即膀胱出口梗阻）改变膀胱、输尿管和 最终肾功能仍然缺乏。 这项建议的具体目的是确定致病因素， 膀胱、输尿管和肾功能障碍的机制 梗阻性尿路病，通过综合功能，形态和 生化研究。 在这个提议中，一个有效的可量化的猫 建立尿道梗阻模型。 两种模型 计划在这个建议：一个高品位，另一个是一个 更温和，更逐步发展的“梗阻”。 一旦 梗阻已经发展，并在尿动力学上表现为 在这两种模型中，随后对神经肌肉结构的研究， 体外收缩性，自主受体密度， 逼尿肌的药理学反应和生化特征 和输尿管肌层将与它们在体内相关 功能，以确定梗阻性膀胱和 输尿管功能障碍 随后，某个 膀胱下梗阻程度对肾功能的影响 - 包括肾血流量、肾小管功能、肾分泌功能 产品和肾小球滤过-将被定义。 形态学 还将确定肾实质的变化， 与功能参数相关。