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STUDIES OF ALPHA-1-ANTITRYPSIN PHENOTYPES AND METABOLISM

STUDIES OF ALPHA-1-ANTITRYPSIN PHENOTYPES AND METABOLISM
ALPHA-1-抗胰蛋白酶表型和代谢的研究
批准号：
3897714
负责人：
E ANTHONY JONES
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3897714
关键词：
Sjogren's syndrome alpha 1 antitrypsin alpha 1 antitrypsin deficiency gel electrophoresis gene expression heterozygote human subject human tissue liver neoplasms population genetics protein metabolism radiotracer rheumatoid arthritis systemic lupus erythematosus

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英文摘要
Protease inhibitor (Pi) phenotype, have been determined using isoelectric focusing on polyacrylamide gel in populations of normal subjects and patients with rheumatoid arthritis, systemic lupus erythematosus, Sjogren's syndrome and hepatocellular carcinoma. The incidence of aberrant (non-MM) phenotypes was not abnormal in any of the four diseases studied, suggesting that alpha-l-antitrypsin deficiency does not play a major role in the pathogenesis of any of these diseases. Using standard tracer methodology to study the turnover of a plasma protein,indices the metabolism of the M and Z alpha-1-antitrypsin molecules have been determined in normal subjects (Pi phenotype MM) and patients with alpha-1-antitrypsin deficiency (Pi phenotype ZZ).
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