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STUDIES OF HEPATIC RECEPTORS FOR GLYCOPROTEINS

STUDIES OF HEPATIC RECEPTORS FOR GLYCOPROTEINS
肝糖蛋白受体的研究
批准号：
3897715
负责人：
E ANTHONY JONES
金额：
$0.0万
依托单位：
NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3897715
关键词：
N acetylglucosamine carbohydrate receptor density gradient ultracentrifugation diabetes mellitus fasting glucose metabolism glycoproteins laboratory rat liver cells liver metabolism mannose membrane proteins perfusion protein metabolism radiotracer receptor tissue /cell culture vascular endothelium

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英文摘要
The cellular location and carbohydrate specificities of a glycoprotein recognition system on rat hepatic sinusoidal cells have been determined. The hepatic receptors which recognize N-acetylglucosamine/mannose terminated glycoproteins are located predominantly on endothelial cells. These receptors are glucose sensitive. Fasting increases the number of these receptors whereas diabetes mellitus abolishes this effect of fasting and impairs the function of this receptor in vivo. These findings suggest a mechanism for abnormal glycoprotein metabolism in diabetes mellitus. This carbohydrate recognition system may play an important role in the removal of potentially autodestructive glycoprotein lysosomal hydrolases and other glycoprotein enzymes from the circulation under normal physiological conditions and in disease states.
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IMMUNOLOGIC STUDIES IN PRIMARY BILIARY CIRRHOSIS
STUDIES OF ALPHA-1-ANTITRYPSIN PHENOTYPES AND METABOLISM
STUDIES RELATING TO THE PATHOGENESIS OF HEPATIC ENCEPHALOPATHY & HEPATIC FAILURE
IMMUNOLOGIC STUDIES IN PRIMARY BILIARY CIRRHOSIS