THE UNIVERSITY OF MICHIGAN MULTIPURPOSE ARTHRITIS CENTER

密歇根大学多功能关节炎中心

• 批准号: 3108151
• 负责人: WILLIAM N KELLEY
• 金额: $ 120.28万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1977
• 资助国家: 美国
• 起止时间: 1977-09-20 至 1992-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3108151
• 关键词: arthritis; osteoarthritis; protein engineering; rheumatoid arthritis

This proposal sets forth a plan for further development of the University of Michigan Multipurpose Arthritis Center (UMAC). Osteoarthritis (OA) is to receive special emphasis in the pilot research area and in a major epidemiologic study. The overall objectives of UMAC continue to include: 1) basic and clinical research dealing with the pathogenesis and treatment of the several rheumatic diseases; 2) continuation of education/training programs for physicians and other health professionals to meet the academic and patient care needs in the field; 3) development of new education programs for specific target groups; 4) expansion of a unique program of community-based education for primary care physicians; and 5) evaluation of each education effort by the best available methodology. Established research programs will be complemented by 9 new pilot research projects that deal with: a new animal model of OA, biochemical mechanisms in OA, new imaging techniques relevant to OA, three different studies of immune cell receptor function, HLA-DR phenotypes in juvenile arthritis, and a virus-induced murine model of polymyositis. Six new educational projects target: teachers in the field of physical education, University students with rheumatoid disease, adults with rheumatoid arthritis, primary care physician trainees, juvenile arthritis patients in the public school setting, and assessment of rheumatoid patients with boutonniere deformities treated by nonsurgical means. In the community programs component a new study of critical factors which determine primary care physician involvement in continuing medical education (CME) in the field of rheumatology is proposed. It will utilize previously collected CME data and also determine how new information reaches the primary care practitioner. The population of Tecumseh, Michigan will be re-examined to measure the incidence, regression, and progression of osteoarthritis and osteoporosis as compared to findings 20 years previously (1962-65). A random probability sample of the entire state of Michigan will also be studied to provide estimates of these two conditions in the general population and to identify possible intervention strategies. These research, education, and community projects will be supported by an Administrative Unit that is integrated into the established organization of the University. A special Tissue Culture Core Unit is proposed for continuation since it supports several of the established research programs within this Center. UMAC has the external support of private and state agencies, as well as the required institutional support, professional, physical, and patient resources to achieve its stated objectives.

这项建议提出了进一步发展的计划 密歇根大学多功能关节炎中心(UMAC)。 骨性关节炎(OA)在飞行员中受到特别重视 在一项重大的流行病学研究中，这是一个重要的研究领域。整体而言 UMAC的目标继续包括：1)基础和临床 几种疾病的发病机制及治疗研究进展 风湿病；2)继续教育/培训方案 供医生和其他健康专业人员与学术人员会面 和现场患者护理需求；3)开发新的 针对特定目标群体的教育方案；4)扩大 独一无二的社区初级保健教育方案 医生；以及5)由最好的人对每项教育工作进行评估 可用的方法。已建立的研究计划将是 与之相辅相成的9个新的试点研究项目涉及：一个新的 骨性关节炎动物模型、骨性关节炎的生化机制、新影像 与骨关节炎相关的技术，三种不同的免疫细胞研究 幼年性关节炎的受体功能、人类白细胞抗原-DR表型和 病毒诱导的多发性肌炎小鼠模型。六大新教育 项目对象：体育领域的教师， 患有风湿病的大学生，患有风湿病的成年人 关节炎、初级保健医生实习生、青少年关节炎 公立学校的患者和类风湿性疾病的评估 采用非手术方法治疗脐部畸形的患者。 社区项目中关键因素的新研究 这决定了初级保健医生是否参与继续 提出了风湿病领域的医学教育(CME)。 它将利用之前收集的CME数据并确定 新信息如何到达初级保健从业者手中。这个 密歇根州特库姆塞的人口将被重新检查，以衡量 骨性关节炎的发生、消退和进展 骨质疏松症与20年前(1962-65)的研究结果相比较。 整个密歇根州的随机概率样本将 中对这两种情况的估计。 并确定可能的干预措施 战略。这些研究、教育和社区项目将 由集成到 大学的既定组织。一种特殊的纸巾 建议延续文化核心单位，因为它支持 该中心内已建立的几个研究项目。 UMAC得到了私人和国家机构的外部支持，如 以及所需的机构支持，专业的，身体的， 和病人资源，以实现其所述的目标。