GENERAL CLINICAL RESEARCH CENTER

该申请寻求五年的一般临床支持 研究中心将设在圣安东尼奥，这是现在的第9大 是美国的一个城市，是200 - 300万人的转诊中心。 住在德克萨斯州南部的人。 该临床研究机构将 包括12张病床，将设在塔河特殊诊断和 Audie L的治疗单位。墨菲纪念退伍军人管理局 医院，德克萨斯大学健康科学教学医院 中心在圣安东尼奥，这是毗邻医学院。 的 目前的设施已经包含了病床，护士，实验室空间， 设备、营养师和膳食辅助器具、办公室、厨房和会议室 一般临床研究中心所需的房间空间。 这 本申请被设计为提供一种用于执行 临床研究的非退伍军人以及退伍军人在这个设施， 这样才能最大限度地利用现有资源。 这笔赠款 申请是一个多学科的临床研究计划 包括内科、儿科、精神科、产科 妇科和药理学。 本提案中的42项协议涵盖 肿瘤中钙、磷和骨代谢等领域 腺苷脱氨酶缺乏和免疫缺陷病 Bartter综合征的病理生理、发病机制和治疗 原发性高血压，青春期生长发育影响因素，发育 治疗肿瘤疾病的新药剂和方法，钾和 肾脏疾病的酸碱平衡，凝集素受体正常， 肿瘤人类淋巴细胞，抑郁症的心理生物学， 食管运动

This application seeks support for five years for a General Clinical Research Center to be situated in San Antonio, which is now the 9th largest city in the United States and is the referral center for the 2-3 million people who live in South Texas. This clinical research facility will consist of 12 beds and will be located in tahe Special Diagnostic and Treatment Unit at the Audie L. Murphy Memorial Veterans' Administration Hospital, a teaching hospital of the University of Texas Health Science Center at San Antonio which is contiguous with the medical school. The current facility already contains the beds, nurses, laboratory space, equipment, dietitian and dietary aids, and office, kitchen and conference room space which is necessary for a General Clinical Research Center. This current application is designed to provide a mechanism for performing clinical reserach on non-veterans as well as veterans in this facility in such a way as to make maximal use of existing resources. This grant application is for a multi-disciplinary program in clinical research involving the Departments of Medicine, Pediatrics, Psychiatry, Obstetrics and Gynecology and Pharmacology. The 42 protocols in this proposal cover areas such as calcium, phosphorus and bone metabolism in neoplastic disease, adenosine deaminase deficiency and immunodeficiency disease, the pathophysiology of Bartter's Syndrome, pathogenesis and treatment of essential hypertension, factors influencing growth at puberty, development of new agents and methods for treating neoplastic disease, potassium and acid-base balance in renal disease, lectin receptors on normal and neoplastic human lymphocytes, the psychobiology of depression and esophageal motility.