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GENETIC STUDIES OF TUMOR SUPPRESSION

GENETIC STUDIES OF TUMOR SUPPRESSION
肿瘤抑制的遗传学研究
批准号：
3939661
负责人：
C C HARRIS
金额：
$0.0万
依托单位：
DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/3939661
关键词：
bronchus cancer registry /resource carcinoma cell population study chromosomes gene expression human tissue hybrid cells karyotype lung neoplasms neoplasm /cancer genetics neoplasm /cancer remission /regression neoplastic cell respiratory epithelium tissue /cell culture

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英文摘要
Genetic changes related to carcinogenesis are being studied using hybrids of human lung carcinoma cells with normal human bronchial epithelial cells. Initial studies suggest that a limited population doubling potential (mortality) is the dominant genetic trait in hybrids cells. Other hybrid cell lines have been isolated and are being characterized for doubling potential, karyotype and tumorigenicity in athymic nude mice. The effects of individual chromosomes are being assessed by fusion with mini-cells containing single marked chromosomes.
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