ENERGY SPECTRA OF CARDIAC SOUNDS

心音的能量谱

• 批准号: 3920110
• 负责人: R E CLARK
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3920110
• 关键词: heart catheterization; heart surgery; human subject; prosthetic heart valve; swine

More than 400 patients have had phonocardiography using a high frequency microphone and accelerometer system. The input is digitized and fast transform fourier analysis applied to the wave fora. Energy in dB versus frequency plots are obtained as are impact or closure sounds to determine synchrony of occluder or leaflet closure. Signatures of normal opening and closing sounds have been obtained. The data were obtained from porcine valves (71 aortic, 124 mitral) and mechanical valves (138 aortic, 58 mitral). More than 100 patients have had the sounds of their prosthetic device measure more than once. Analysis have shown for the aortic porcine that the peak frequency of the systolic ejection murmur is tightly correlated to the frequency of maximal closure energy more than 20 valves have been shown to be dysfunctional both by energy spectra analysis and cardiac catheterization studies. Replacement of the fatigued prosthetic valve has been performed in most cases. Pathologic studies confirm marked leaflet calcification and fatigue. Several more years of tracking the same patient will be required before the predictive value of acoustic energy spectra recording can be established as a screening method for patients with bioprosthetic valves.

超过 400 名患者使用高频心音图进行了心音图检查 频率麦克风和加速度计系统。 输入是 应用于波的数字化和快速变换傅立叶分析 论坛。 获得的能量（以 dB 为单位）与频率图如下 撞击或闭合声音以确定封堵器或 传单关闭。 正常打开和关闭声音的特征 已获得。 数据来自猪瓣膜（71 主动脉瓣、二尖瓣 124 瓣）和机械瓣膜（主动脉瓣 138、二尖瓣 58 瓣）。 超过 100 名患者听到了假肢的声音 设备多次测量。 分析表明，对于主动脉 猪收缩期射血杂音的峰值频率为 与最大闭合能量的频率密切相关 超过 20 个阀门已被证明在能量方面出现功能障碍 光谱分析和心导管插入术研究。 替代品 大多数情况下都会对疲劳的人工瓣膜进行修复。 病理学研究证实明显的小叶钙化和 疲劳。 对同一个病人的追踪还要再持续几年 声能谱预测值之前需要 可以建立记录作为患者的筛查方法 与生物瓣膜。