OUTPATIENT CLINIC FOR GENETIC AND PHARMACOLOGIC STUDIES OF AFFECTIVE DISORDERS

情感障碍遗传和药理学研究门诊

• 批准号: 3921851
• 负责人: W H BERRETTINI
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3921851
• 关键词: Alzheimer's disease; Huntington's disease; Parkinson's disease; Tourette's syndrome; adolescence (12-20); bulimia nervosa; cerebrospinal fluid; clonidine; computed axial tomography; disease /disorder proneness /risk; genetic markers; human population genetics; human subject; melatonin; neuropeptide Y; neuropharmacology; neurophysiology; neurotransmitter metabolism; physostigmine; postmortem; psychopharmacology

A longitudinal prospective study of adolescents at high risk for affective disorder is continuing. A biological marker, the suppression of plasma melatonin by light, differentiates the "high- risk" adolescents from a control adolescent group. CSF dynorphin A1-8 immunoreactivity is significantly elevated in Tourette's Syndrome compared to age and sex matched controls. The degree of elevation is significantly correlated with severity of obsessive-compulsive behavior (but not with severity of motor tics), suggesting that this peptide may play a role in pathophysiology of this disorder. Post-mortem ventricular fluid (PMVF) was obtained at autopsy from subjects with Alzheimer's disease (AD), Huntington's disease (PD) and controls dying of cause not related to the CNS. Measurements of galanin, neuropeptide Y, and somatostatin revealed that all were significantly elevated in every patient group compared to the controls, findings that are contrary to in vivo lumbar CSF studies, suggesting that PMVF may not be a valid approach to the study of neuropeptides in diseases states.

对有高风险的青少年的纵向前瞻性研究 情感障碍仍在继续。 生物标记， 通过光抑制血浆褪黑激素，区分了“高 - 风险“来自对照青少年组的青少年。 CSF Dynorphin A1-8免疫反应性显着升高 与年龄和性匹配的对照组相比，图雷特综合征。 这 高程程度与严重程度显着相关 强迫性行为（但没有电动机的严重程度 TICS），建议这种肽可能在 这种疾病的病理生理。 尸检时从 阿尔茨海默氏病（AD），亨廷顿氏病（PD）的受试者 并控制与中枢神经系统无关的原因死亡。 测量 Galanin，Neuropepide Y和生长抑素揭示了所有人 与 对照，与体内腰CSF研究相反的发现， 暗示PMVF可能不是研究的有效方法 疾病状态中的神经肽。