SIMIAN RETROVIRUSES

D型猿类逆转录病毒(SRV)继续地方性感染 ORPRC的短尾猴、短尾猴和黑尾猕猴。 目前有四种不同的SRV代表三种血清学类型 在一个或多个物种中。这些SRV的密切相关变体是 也在现场。类型之间的直接因果关系 D-SRV和猴免疫缺陷综合征(SAID)几乎是 当然。疾病(或缺乏)的表现可能取决于 关于SRV的侵染性变种及其种类。机制(S) 导致免疫缺陷的原因在很大程度上是未知的。延续 拟议的监督和管理计划可能会导致 在建立无SRV的D型猕猴群体中。 建议进行研究以表征合成的SRV-2外膜 SRV的多肽、细胞趋向性及其分子差异 在变异病毒的包膜区域，有不同的疾病 表情。重点是确定病毒宿主细胞的特征。 确定宿主中哪些细胞为目标的相互作用 通过类型D SRV作为定义负责以下各项的机制的步骤 免疫抑制。

Type D simian retroviruses (SRVs) continue to endemically infect Macaca fuscata, Macaca mulatta, and Macaca nigra at the ORPRC. Four distinct SRVs representing three serologic groups are present in one or more species. Closely related variants of these SRVs are also present. A direct cause and effect relationship between type D SRVs and simian immunodeficiency syndrome (SAIDS) is almost certain. Expression of disease (or lack of) is likely dependent on the infecting variant of SRV and species. The mechanism(s) leading to immunodeficiency are largely unknown. Continuation of proposed surveillance and management programs will likely result in the establishment of type D SRV-free macaque colonies. Studies are proposed to characterize synthetic SRV-2 envelope peptides, cellular tropism of SRVs, and the molecular differences in the envelope region of variant viruses, with different disease expression. The focus is to characterize the virus-host cell interactions that determine which cells in the host are targeted by type D SRVs as a step in defining mechanisms responsible for immunosuppression.