课题基金 / 基金详情

SIMIAN RETROVIRUSES

SIMIAN RETROVIRUSES
猴逆转录病毒
批准号:
3926104
负责人:
ROBERT D KOLER
金额:
$0.0万
依托单位国家:
美国
项目类别:
财政年份:
--
资助国家:
美国
项目状态:
未结题
起止时间:
至

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中文摘要
翻译
D型猿猴逆转录病毒(srv)继续地方性感染
英文摘要
Type D simian retroviruses (SRVs) continue to endemically infect Macaca fuscata, Macaca mulatta, and Macaca nigra at the ORPRC. Four distinct SRVs representing three serologic groups are present in one or more species. Closely related variants of these SRVs are also present. A direct cause and effect relationship between type D SRVs and simian immunodeficiency syndrome (SAIDS) is almost certain. Expression of disease (or lack of) is likely dependent on the infecting variant of SRV and species. The mechanism(s) leading to immunodeficiency are largely unknown. Continuation of proposed surveillance and management programs will likely result in the establishment of type D SRV-free macaque colonies. Studies are proposed to characterize synthetic SRV-2 envelope peptides, cellular tropism of SRVs, and the molecular differences in the envelope region of variant viruses, with different disease expression. The focus is to characterize the virus-host cell interactions that determine which cells in the host are targeted by type D SRVs as a step in defining mechanisms responsible for immunosuppression.
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ASIP-OREGON HEALTH SCIENCES UNIVERSITY
SUPPORT FOR REGIONAL PRIMATE RESEARCH CENTER
SUPPORT FOR REGIONAL PRIMATE RESEARCH CENTER
DIVISION OF REPRODUCTION BIOLOGY AND BEHAVIOR
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海外基金
基于多组学技术研究肠道微生物在猕猴(Macaca mulatta)衰老过程中的作用机制
  • 批准号:
    32370450
  • 项目类别:
    面上项目
  • 资助金额:
    50万元
  • 批准年份:
    2023
  • 负责人:
    范振鑫
  • 依托单位:
太行山猕猴(Macaca mulatta tcheliensis)雌性的配偶选择
  • 批准号:
    32070446
  • 项目类别:
    面上项目
  • 资助金额:
    58.0万元
  • 批准年份:
    2020
  • 负责人:
    路纪琪
  • 依托单位:
猕猴(Macaca mulatta)衰老过程中凝血功能变化规律及基因表达调控机制研究
  • 批准号:
    --
  • 项目类别:
    --
  • 资助金额:
    58万元
  • 批准年份:
    2020
  • 负责人:
    范振鑫
  • 依托单位:
猕猴(Macaca mulatta)衰老过程中凝血功能变化规律及基因表达调控机制研究
  • 批准号:
    32070413
  • 项目类别:
    面上项目
  • 资助金额:
    58.0万元
  • 批准年份:
    2020
  • 负责人:
    范振鑫
  • 依托单位: