FETAL EFFECTS OF LIDOCAINE OR CHLOROPROCAINE IN MATERNAL ANESTHESIA

利多卡因或氯普鲁卡因在产妇麻醉中对胎儿的影响

• 批准号: 3926397
• 负责人: BETTY R. KUHNERT
• 金额: --
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3926397
• 关键词: child psychology; embryo /fetus drug adverse effect; enzyme mechanism; epidural anesthesia; human fetus tissue; human pregnant subject; human subject; lidocaine; local anesthesia; obstetric anesthesia

The purpose of this protocol is to test the hypothesis that following epidural, pudendal, or local perineal infiltration anesthesia, equi-effective doses of an ester-linked local anesthetic (chloroprocaine) will have less of an observable effect on the fetus and neonate than an amide-linked local anesthetic (lidocaine) due to the rapid enzymatic hydrolysis of ester-lined compounds.

该协议的目的是检验以下假设： 硬膜外、阴部或局部会阴浸润后 麻醉，等效剂量的酯连接局部麻醉剂 麻醉剂（氯普鲁卡因）的可观察效果较小 对胎儿和新生儿的影响优于酰胺联局部麻醉剂 （利多卡因）由于酯衬里的快速酶促水解 化合物。