DHPR ? subunit binding to a variably spliced region of RyR1: a role in EC coupling and myotonic dystrophy

DHPR？

• 批准号: nhmrc : 1002589
• 负责人: A/Pr Marco Casarotto
• 金额: $ 37.07万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/dhpr-subunit-binding-myotonic-dystrophy/108832
• 关键词: DHPR; subunit; binding; variably; spliced

We have uncovered a communication pathway between two ion channel molecules in muscle cells that underlies human movement. The pathway is critical in normal mobility and is disrupted in myotonic dystrophy. We will study the molecular components of this pathway to understand normal body function and abnormal function in mytotonic dystrophy. The work will facilitate the design of drugs to relieve the mytotonic dystrophy myopathy and form new and much needed class of specific muscle relaxants.

我们已经发现了肌肉细胞中两个离子通道分子之间的通信途径，这是人体运动的基础。该途径在正常活动中至关重要，在强直性肌营养不良中被破坏。我们将研究这一途径的分子组成部分，以了解正常的身体功能和肌强直性营养不良症的异常功能。这项工作将促进药物的设计，以减轻肌强直性营养不良性肌病，并形成新的和急需的一类特定的肌肉松弛剂。