Glutathione transferase-derived compounds as therapeutic agents

作为治疗剂的谷胱甘肽转移酶衍生化合物

• 批准号: nhmrc : 471462
• 负责人: A/Pr Marco Casarotto
• 金额: $ 27.91万
• 依托单位: Australian National University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/glutathione-transferase-derived-therapeutic-agents/77300
• 关键词: Glutathione; transferase; derived; compounds; therapeutic

Inhibition of cardiac calcium ion channels may be an effective new way of improving heart performance in patients with heart failure. This project will investigate how a glutathione transferase enzyme inhibits calcium ion channels in the heart and if small fragments of a muscle specific glutathione transferase can be used to specifically modify cardiac ryanodine receptor function. These fragments will provide the basis for the development of a new therapeutic approach.

抑制心脏钙离子通道可能是改善心力衰竭患者心脏功能的一种有效新方法。本项目将研究谷胱甘肽转移酶如何抑制心脏中的钙离子通道，以及肌肉特异性谷胱甘肽转移酶的小片段是否可用于特异性修饰心脏兰尼碱受体功能。这些片段将为开发新的治疗方法提供基础。