COMPUTER FOR ULTRASTRUCTURE RESEARCH & MOLECULAR BIOLOGY

用于超微结构研究的计算机

• 批准号: 3519908
• 负责人: JOACHIM FRANK
• 金额: $ 30万
• 依托单位: NYSDOH/HEALTH RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 1988
• 资助国家: 美国
• 起止时间: 1988-06-27 至 1989-06-26
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3519908
• 关键词: biomedical equipment purchase; biomedical equipment resource; computed axial tomography; computer center; electron microscopy; molecular biology

Support is requested fro a computer facility serving the group of principal investigators of NIH grants in projects of ultrastructural research and molecular biology. Emphasis is on projects in the areas of structural biology using the conventional electron microscope and computer tomography using the high voltage electron microscope. The range of biological structures encompassed by these projects include ribosomes and enzyme complexes, cilia, components of the mitotic apparatus, and whole cell reconstructions. The projects relate to issues of the fundamental structure of macromolecular complexes and organelles as well as to specific disease and developmental processes. Most of the computer-based components of these projects rely on the availability of raster graphics, large disk space and memory. The use of a shared facility is appropriate because the bulk of the existing software developed in-house has been written with a view towards accommodating a wide range of applications, and because such a facility leads to the most efficient utilization of resources.

请求为该组提供服务的计算机设施提供支持 NIH 超微结构项目资助的主要研究人员 研究和分子生物学。 重点是结构生物学领域的项目，使用 传统电子显微镜和计算机断层扫描使用 高压电子显微镜。 生物范围 这些项目涵盖的结构包括核糖体和 酶复合物、纤毛、有丝分裂装置的成分、 和全细胞重建。 这些项目涉及以下问题 大分子复合物的基本结构和 细胞器以及特定疾病和发育 流程。 这些的大部分基于计算机的组件 项目依赖于光栅图形、大磁盘的可用性 空间和记忆。 使用共用设施是适当的 因为现有的大部分内部开发的软件已经 编写的目的是为了适应广泛的 应用程序，并且因为这样的设施导致最 资源的有效利用。