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An Investigation of Auditory Processes in Parkinson's Disease: Risk Factors and the Potential Utility of Corrective Hearing Treatments.

帕金森病听觉过程的调查：风险因素和矫正听力治疗的潜在效用。

基本信息

批准号：
ES/X004082/1
负责人：
Megan Readman
金额：
$ 11.84万
依托单位：
Lancaster University
依托单位国家：
英国
项目类别：
Fellowship
财政年份：
2022
资助国家：
英国
起止时间：
2022 至无数据
项目状态：
已结题

来源：
https://gtr.ukri.org/projects?ref=ES%2FX004082%2F1
关键词：
Investigation Auditory Processes Parkinson Disease

项目摘要

Parkinson's Disease (PD), the second most pervasive neurodegenerative disorder after Alzheimer's Disease (3), is a multifaceted movement disorder, which currently affects ~137,000 people in the UK (4,5). While we know that PD occurs due to the progressive loss of dopamine neurons in the basal ganglia of the brain (6), we do not know what causes the loss of dopamine neurons to occur. Subsequently, PD is currently incurable (7). Therefore, the management, and identification of potential risk factors associated with PD is of particular clinical importance. PD and dementia, particularly dementia with Lewy bodies, share similar neuropathologies, brain chemistry, and symptoms (8). Importantly, approximately 80% of people with PD are affected by dementia (9). Hearing loss is a potentially modifiable risk factor for dementia, such that even mild hearing loss doubles dementia risk (10). Given the interrelatedness of dementia and PD, it may be that hearing loss is also a potentially modifiable risk factor for PD. While some studies have begun to acknowledge the relatedness of PD and hearing loss, large scale analyses are needed to fully determine whether hearing loss is a risk factor of PD or whether hearing loss is a secondary consequence of impaired sensory processing or medication consumption that occurs over the course of PD progression. Therefore, I propose to conduct a large-scale secondary data analysis, using the UK Biobank, of the relatedness of hearing loss, the diagnosis of PD the severity of Parkinsonian symptomology, anti-Parkinsonian medication consumption, and demographics (e.g. race, sex, and nationality). This analysis will be conducted in collaboration with renowned researchers in the fields of auditory neuroscience (Prof. Plack; ManCAD, SENSE-Cog, C4AR), neurodegeneration (Prof. Crawford; C4AR), and perception (Dr Linkenauger). Health inequalities are disparities in our understanding, and treatment, of health conditions. Although, North African and Ashkenazi Jewish individuals are more likely to develop PD, ethnic minorities are grossly underrepresented in research. Akin to the ESRC objectives, Parkinson's UK has launched an initiative that aims to tackle health inequalities. In line with these objectives, the proposed study will also analyse the influence of demographic characteristics including race, nationality and sex, on (a) the overall occurrence of PD and (b) the relatedness of hearing loss and PD.The proposed fellowship aims to:(i) Disseminate findings with academics: Previous PhD findings, and new findings will be presented at large international conferences and through peer-reviewed publications. (ii) Generate non-academic output: In collaboration with Professor Hedley Emsley, I will organise a research symposium (targeted to individuals working with people with PD). I will also organise a research workshop for individuals with PD. In addition to these workshops, a summary infographic will be developed and shared with workshop/symposium attendees, members of Lancashire Teaching Hospitals NHS Foundation Trust, Lancashire Neuroscience, and the C4AR. (iii) Conduct a large-scale secondary data analysis investigating the relatedness of hearing loss and PD (using the UK Biobank). The results of these exploratory analyses will form the basis of funding applications.(iv) Enhance my research skills and collaborative networks: By completing additional research, I will enhance my data analysis skills and develop new collaborations with experts in the field. These skills and collaborations will allow me to conduct further research in the future. (v) Develop funding applications: During the fellowship, I will develop funding applications: The ESRC New Investigator grant, and the ESRC Secondary Data Analysis Initiative. These grants will investigate the propensity and effects of hearing loss in individuals with both early stage and advanced PD, and the potential utility of treatments to correct hearing loss in PD

帕金森病(PD)是仅次于阿尔茨海默病(3)的第二大最普遍的神经退行性疾病(3)，是一种多方面的运动障碍，目前在英国约有137,000人受到影响(4，5)。虽然我们知道帕金森病的发生是由于大脑基底节多巴胺神经元的进行性丧失(6)，但我们不知道是什么导致了多巴胺神经元的丧失。因此，帕金森病目前是不治之症(7)。因此，管理和识别与帕金森病相关的潜在危险因素具有特别重要的临床意义。帕金森病和痴呆症，特别是路易体痴呆症，有着相似的神经病理、脑化学和症状[8]。重要的是，大约80%的帕金森氏症患者患有痴呆症(9)。听力损失是痴呆症的一个潜在的可改变的风险因素，因此即使是轻微的听力损失也会使痴呆症的风险加倍(10)。鉴于痴呆症和帕金森病的相互关联，听力损失也可能是帕金森病的一个潜在的可改变的危险因素。虽然一些研究已经开始承认帕金森病与听力损失的相关性，但需要进行大规模的分析来充分确定听力损失是否是帕金森病的危险因素，或者听力损失是否是在帕金森病进展过程中发生的感觉处理或药物消耗受损的次要后果。因此，我建议使用英国生物库进行一项大规模的二级数据分析，分析听力损失的相关性、帕金森氏症的诊断、帕金森综合症的严重性、抗帕金森症的药物消费以及人口统计数据(如种族、性别和国籍)。这项分析将与听神经科学(Plack教授；ManCAD，Sense-Cog，C4AR)、神经变性(Crawford教授；C4AR教授)和感知(Linkenauger博士)领域的知名研究人员合作进行。健康不平等是我们对健康状况的理解和治疗方面的差异。虽然，北非和德系犹太人更容易患上帕金森病，但少数民族在研究中的代表性严重不足。与ESRC的目标类似，帕金森英国已经发起了一项旨在解决健康不平等问题的倡议。根据这些目标，拟议的研究还将分析人口特征，包括种族、国籍和性别，对(A)帕金森病的总体发生情况和(B)听力损失与听力障碍的相关性的影响。拟议的研究金旨在：(I)与学者传播研究结果：以前的博士研究结果，新的研究结果将在大型国际会议上和通过同行评议的出版物提出。(Ii)产生非学术成果：我将与Hedley Emsley教授合作，组织一次研究研讨会(针对与帕金森病患者共事的个人)。我还将为帕金森病患者组织一个研究工作坊。除了这些研讨会外，还将制作一份摘要信息图表，并与研讨会/研讨会与会者、兰开夏郡教学医院NHS基金会信托基金、兰开夏郡神经科学和C4AR的成员分享。(Iii)进行大规模的二级数据分析，调查听力损失与帕金森病的相关性(使用英国生物库)。这些探索性分析的结果将成为资助申请的基础。(Iv)增强我的研究技能和合作网络：通过完成更多的研究，我将增强我的数据分析技能，并与该领域的专家开展新的合作。这些技能和合作将使我能够在未来进行进一步的研究。(V)开发资助应用程序：在奖学金期间，我将开发资助应用程序：ESRC新研究人员补助金和ESRC二级数据分析倡议。这些赠款将调查早期和晚期帕金森病患者听力损失的倾向和影响，以及治疗帕金森病患者听力损失的潜在效用。