OPERATION FOR HYPERTROPHIC SUBAORTIC STENOSIS IN THE ELDERLY

老年人肥厚性主动脉下狭窄的手术治疗

• 批准号: 3942867
• 负责人: M M COOPER
• 金额: --
• 依托单位: NATIONAL HEART, LUNG, AND BLOOD INSTITUTE
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3942867
• 关键词: aging; aortic valve stenosis; heart output disorder; human subject; human therapy evaluation; hypertrophic myocardiopathy; longitudinal human study; medical complication

The hypothesis tested in this study was that the septal myectomy operation for palliative treatment of hypertrophic cardiomyopathy was equally worthwhile in those 65 years and older as has been shown for younger patients. 52 patients for whom complete data were available for greater than 5 years after the operation or until death comprised the study. The mean age was 69 plus or minus 3 years (range 65-81) 57% of whom were female. 41 patients had no coronary artery disease (CAD) requiring surgical palliation. The remainder had CAD. 82 and 95% reduction in peak left ventricular outflow pressure gradients was achieved in the two groups, respectively. An 8% hospital mortality and 75 plus or minus 8% 5 year survival was achieved in those without CAD. Those with CAD had increased hospital mortality and lower 5 year survival rates. These data support the clinical impression that older age is not a contraindication to operative palliation although the presence of significant CAD increases risk.

在这项研究中检验的假设是，隔肌切除术 肥厚性肥厚症姑息性手术治疗 在这65年里，心肌病同样值得一试 年龄较大的患者表现为较年轻的患者。52名患者接受治疗 他们的完整数据在5年后仍可用 手术或死亡构成了这项研究。平均年龄 69岁正负3岁(65-81岁)其中57%是 女性。41例患者无冠状动脉疾病(CAD) 需要手术姑息。其余患者均患有冠心病。82和 左心室流出道峰压差降低95% 分别在两组中达到。一家8%的医院 死亡率和75%的5年生存率为8%或8% 那些没有CAD的。那些患有冠心病的人增加了住院时间 死亡率和较低的5年生存率。这些数据支持 临床印象中年龄较大并不是 手术姑息，尽管存在显著的冠心病 增加风险。