PHYSICAL/NEUROLOGICAL DEVELOPMENT IN CHILDREN OF HEALTH AND DEPRESSED MOTHER

母亲患有抑郁症的健康儿童的身体/神经发育

• 批准号: 3944794
• 负责人: T SHERMAN
• 金额: --
• 依托单位: NATIONAL INSTITUTE OF MENTAL HEALTH
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3944794
• 关键词: behavioral genetics; child mental disorders; child physical development; child psychology; human subject; mental disorder diagnosis; nervous system disorder diagnosis; neurologic manifestations; parent offspring interaction; sign /symptom

The exciting current work on the biochemical and genetic bases of the major affective disorders makes more salient the need to bridge the sciences and begin to develop concepts and markers linking the physical and neurological substrate with the complex behavioral manifestations of these disorders. A developmental framework provides a basis for moving beyond correlational assessment to causal modeling. The project will be a step in this process. A rich body of data on the children's birth complications, physical development, cognitive development and neurological development will be brought together as profiles for individual children. These profiles will be subjected to a cluster analysis. It is expected that some of the clusters of children will be associated with higher family loadings for affective illness. It is also expected that particular clusters will be associated with specific social, emotional, and/or cognitive outcomes, or with the development of symptoms of affective illness, and/or behavioral disorders in the children.

目前在生物化学和遗传学基础上的令人兴奋的工作 严重的情感障碍使人们更加需要 架起科学的桥梁，开始开发概念和标记 将生理和神经底物与复合体联系起来 这些障碍的行为表现。发展中的 框架为超越相关性提供了基础 对因果模型的评估。该项目将是这方面的一个步骤 进程。 关于孩子出生并发症、身体状况的丰富数据 发展、认知发展与神经学 发展将作为个人配置文件集中在一起 孩子们。将对这些概况进行聚类分析。它 预计其中一些儿童集群将被 与情感性疾病的家庭负担较高有关。它是 还预计特定的群集将与 特定的社会、情感和/或认知结果，或与 情感性疾病症状的发展，和/或行为 儿童的精神障碍。