Generating impact to prevent cancer in people with Lynch syndrome

为林奇综合征患者预防癌症产生影响

• 批准号: ES/Y00759X/1
• 负责人: Kelly Lloyd
• 金额: $ 15.79万
• 依托单位: University of Leeds
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=ES%2FY00759X%2F1
• 关键词: Generating; impact; prevent; cancer; people

The National Institute for Health and Care Excellence (NICE) is a government organisation that produces guidelines for the National Health Service (NHS). NICE recommends that healthcare professionals should consider prescribing daily aspirin to prevent bowel cancer in people with a genetic condition called Lynch syndrome. Lynch syndrome increases the risk of developing a spectrum of cancers, including bowel. Future national guidance may recommend aspirin for cancer prevention in the general population, similar to Australian recommendations. In my PhD, I investigated the barriers to implementing aspirin for cancer prevention into the NHS. I studied the views of people with Lynch syndrome, the general population, and healthcare professionals. I concluded that coordinated strategies, which address the needs of patients and healthcare professionals, are required to implement aspirin for cancer prevention into the NHS. I identified individuals with Lynch syndrome for whom aspirin was not appropriate, highlighting a need for new cancer prevention initiatives for these people. In the ESRC Fellowship, I will enhance my PhD impact, and further develop my training and publication track record. I will develop a competitive funding proposal, which will secure my position as a future leader in behavioural research.PhD research event engaging with different audiencesI will host an online event showcasing my PhD findings, focusing on the findings related to people with Lynch syndrome. I will moderate a session for attendees to discuss how to implement the findings into policy and clinical practice. I will invite key stakeholders, including people with Lynch syndrome, research scientists, and representatives from relevant organisations (e.g., Cancer Research UK, NICE). I will share a summary of the event and agreed recommendations for policy and practice through the charity Lynch Syndrome UK, and the British Journal of General Practice.Publication of final PhD studyI have published three of my four PhD studies in leading health journals. My third study explored the views of the general population on aspirin for bowel cancer prevention. I will submit the study for publication in Preventive Medicine Reports.Limited new researchIn my PhD, I interviewed 15 people with Lynch syndrome to discuss their views on aspirin for bowel cancer prevention. In these interviews, other key preventive approaches were discussed, such as diet and exercise to prevent obesity-related cancers. Weight management could be an important complementary or alternative strategy to aspirin for cancer prevention. I will allocate 20% of the Fellowship to re-analysing these interviews, and conducting 10 new interviews to explore participants' views on weight management to prevent cancer. I will submit the study for publication in Familial Cancer, and present at the International Behavioural Trials Network Conference.Funding proposalI will develop a funding proposal to adapt a weight management intervention to prevent cancer in people with Lynch syndrome with overweight or obesity. During the design of the proposal, I will seek out the views of patient representatives, and expert researchers. I will consider several funding schemes, including the ESRC New Investigator Grant. I will submit the proposal by the end of the ESRC Postdoctoral Fellowship.TrainingI will undertake training to enhance my research skills, and network with leading international behavioural researchers. I will apply to attend:- International Agency for Research on Cancer summer school 2024 programme in Lyon, France.- International Behavioural Trials Network 2024 summer school and conference in Montréal, Canada.- University of Oxford course: 'Randomised Control Trials Course: A Guide to Design, Conduct, Analysis, Interpretation and Reporting'.This Fellowship is aligned with the Wellbeing, Health and Communities pathway, which aims to address challenges such as obesity.

国家健康和护理卓越研究所（NICE）是一个政府组织，为国家卫生服务（NHS）制定指导方针。NICE建议，医疗保健专业人员应该考虑每天开阿司匹林处方，以预防患有林奇综合征遗传疾病的人患肠癌。林奇综合征会增加患一系列癌症的风险，包括肠癌。未来的国家指南可能会推荐阿司匹林用于一般人群的癌症预防，类似于澳大利亚的建议。在我的博士学位，我调查了实施阿司匹林预防癌症到NHS的障碍。我研究了林奇综合征患者、普通人群和医疗保健专业人员的观点。我得出的结论是，协调的战略，解决病人和医疗保健专业人员的需求，需要实施阿司匹林预防癌症到国民保健服务。我确定了林奇综合征患者不适合服用阿司匹林，强调需要为这些人采取新的癌症预防措施。在ESRC奖学金，我将提高我的博士学位的影响，并进一步发展我的培训和出版跟踪记录。我将制定一个有竞争力的资金提案，这将确保我作为行为研究的未来领导者的地位。博士研究活动与不同的观众互动我将举办一个在线活动，展示我的博士研究成果，重点是与林奇综合征患者相关的研究结果。我将主持一个会议，让与会者讨论如何将研究结果落实到政策和临床实践中。我将邀请主要利益相关者，包括林奇综合征患者、研究科学家和相关组织的代表（例如，英国癌症研究所，NICE）。我将通过慈善机构Lynch Syndrome UK和《英国全科医学杂志》分享这次活动的总结和商定的政策和实践建议。最后的博士研究论文的出版我已经在领先的健康期刊上发表了我四篇博士研究论文中的三篇。我的第三项研究探讨了普通人群对阿司匹林预防肠癌的看法。在我的博士学位期间，我采访了15名林奇综合征患者，讨论他们对阿司匹林预防肠癌的看法。在这些访谈中，讨论了其他关键的预防方法，如饮食和运动，以预防肥胖相关的癌症。体重管理可能是阿司匹林预防癌症的重要补充或替代策略。我将拨出20%的研究金，重新分析这些访谈，并进行10次新的访谈，以探讨参与者对体重管理以预防癌症的看法。我将提交研究发表在家族性癌症，并在国际行为试验网络Conference.Funding proposalI将制定一个资金建议，以适应体重管理干预，以预防癌症的林奇综合征与超重或肥胖的人。在设计方案时，我会征询病人代表和专家研究人员的意见。我将考虑几个资助计划，包括ESRC新研究者补助金。我将在ESRC博士后奖学金结束前提交建议书。培训我将接受培训以提高我的研究技能，并与国际领先的行为研究人员建立联系。我将申请参加：-国际癌症研究机构暑期学校2024计划在里昂，法国。国际行为试验网络2024年夏季学校和会议在蒙特利尔，加拿大。牛津大学课程：“随机对照试验课程：设计，执行，分析，解释和报告指南”。该奖学金与福利，健康和社区途径保持一致，旨在应对肥胖等挑战。