METHODS TO DETECT HIV AND RELATED RETROVIRUSES

检测艾滋病毒和相关逆转录病毒的方法

• 批准号: 3596165
• 负责人: MAURICE ROSENSTRAUS
• 金额: $ 51.77万
• 依托单位: ENZO BIOCHEM, INC.
• 依托单位国家: 美国
• 财政年份: 1987
• 资助国家: 美国
• 起止时间: 1987-06-01 至 1990-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3596165
• 关键词: AIDS; Retroviridae; human immunodeficiency virus 1; immunological substance; rapid diagnosis; virus classification

Since the discovery of the human immunodeficiency virus (HIV) as the etiological agent of AIDS, research efforts directed toward the epidemiology, prevention, pathogenesis, and adequate treatment of both the underlying disease and is sequelae have been intensified. However, several aspects of the work have been hampered by the lack of relatively simple, rapid and quantitative methods for detecting the virus or its constituent antigens in experimental systems or clinical materials. The successful development of improved methods would enhance research on all aspects of AIDS throughout the scientific community but would especially benefit work of the AIDSP toward the development of vaccines and therapeutic regimens. The lack of rapid, quantitative assays coupled with the present paucity of animal model systems for the infection makes the development of therapies and vaccines particularly difficult. The objective of this contract is to assure that simpler, faster, and quantitative methods for the detection of HIV and related retroviruses will be developed in the most expeditious manner. The end product(s) of this research should permit the ready detection and measurement of HIV and related retroviruses in clinical, animal and laboratory specimens.

自从人类免疫缺陷病毒（HIV）被发现以来， 艾滋病的病原体，研究工作针对 流行病学，预防，发病机制和适当的治疗， 基础疾病和后遗症已经加剧。 但几 由于缺乏相对简单， 检测病毒或其成分的快速定量方法 实验系统或临床材料中的抗原。 成功 发展改进的方法将加强对所有方面的研究， 艾滋病席卷整个科学界，但对工作尤其有益 艾滋病战略计划的目标是开发疫苗和治疗方案。 缺乏快速、定量的检测方法，加上目前缺乏 感染的动物模型系统使得治疗方法的发展 疫苗尤其困难。 本合同的目的是 确保更简单，更快，定量检测方法， 艾滋病毒和相关的逆转录病毒将以最快的速度发展， 方式 本研究的最终产品应允许准备好的 在临床上检测和测量HIV和相关逆转录病毒， 动物和实验室标本。