Mu-opioid receptor desensitization in ventral tegmental neurones: cellular mechanisms and functional consequences

腹侧被盖神经元的μ阿片受体脱敏：细胞机制和功能后果

• 批准号: G0701486/1
• 负责人: Christopher Bailey
• 金额: $ 52.42万
• 依托单位: University of Bath
• 依托单位国家: 英国
• 项目类别: Research Grant
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0701486%2F1
• 关键词: Mu; opioid; receptor; desensitization; ventral

Opiate drugs such as morphine and heroin are widely abused, with approximately 270,000 problem opiate users in the UK. When somebody uses opiates consistently for a while, they become tolerant to its effects and need to use more to get the ?high? they initially experienced and to stave off withdrawal. This process of tolerance contributes to the health and social problems inherent in opiate addiction. To date the mechanism(s) underlying the development of morphine tolerance remain unknown. In this proposal we will investigate opiate tolerance on a single cellular level, in order to investigate potential intracellular signalling mechanisms that may underlie the development of opiate tolerance. We will then go on to study how interfering with these signalling mechanisms can affect the development of opiate tolerance. It is only by understanding how morphine tolerance occurs on a cellular level that we can begin to design better treatments for opiate abuse in the future.

鸦片类药物如吗啡和海洛因被广泛滥用，在英国大约有27万问题鸦片使用者。当一个人持续使用阿片类药物一段时间后，他们就会对其效果产生耐受性，需要使用更多的阿片类药物来获得快感。他们最初经历和延缓戒断。这种容忍过程助长了阿片类药物成瘾所固有的健康和社会问题。迄今为止，吗啡耐受性形成的机制尚不清楚。在这一建议中，我们将在单个细胞水平上研究阿片类药物耐受性，以研究可能导致阿片类药物耐受性发展的潜在细胞内信号机制。然后我们将继续研究干扰这些信号机制如何影响阿片类药物耐受性的发展。只有了解吗啡耐受性是如何在细胞水平上发生的，我们才能开始设计更好的治疗阿片类药物滥用的方法。