Motivational processing, Mesolimbic and Mesostriatal Function in Neuropsychiatric Disease

神经精神疾病中的动机处理、中脑边缘和中纹状体功能

• 批准号: G0701911/1
• 负责人: Graham Murray
• 金额: $ 92.59万
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Fellowship
• 财政年份: 2009
• 资助国家: 英国
• 起止时间: 2009 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=G0701911%2F1
• 关键词: Motivational; processing; Mesolimbic; Mesostriatal; Function

Motivation and the response to rewarding events are adversely affected in many psychiatric and neurological illnesses: many patients with psychosis or Parkinson‘s Disease (PD) are de-motivated and experience apathy. Also, patients with some illnesses, such young adults with psychosis, seem to be over motivated by irrelevant information, which they seem to find captivating. This can also happen in patients with PD, possibly secondary to medication. But very little is known about the precise cause of these motivational abnormalities at the brain level. One reason is why few studies have even tried to investigate these processes in patients is because, until very recently, the techniques and methods to study brain motivational processes in patients were underdeveloped. Recent advances in (a) MRI brain imaging, and (b) basic understanding of reward and motivational processing, have meant that the time is now ripe to study how these processes are affected in psychiatric and neurological illness. I will study patients with psychosis, and PD, and examine to what extent their apathy and psychotic symptoms can be related to abnormalities in motivational and reward processing systems. Greater understanding will be helpful to patients, will enable better use of existing treatments and could help develop new treatments.

动机和对奖励事件的反应在许多精神病和神经系统疾病中受到不利影响：许多精神病或帕金森病（PD）患者缺乏动机并经历冷漠。此外，患有某些疾病的患者，如患有精神病的年轻人，似乎会被无关的信息过度激励，他们似乎觉得这些信息很吸引人。这也可能发生在PD患者中，可能继发于药物治疗。但是，我们对大脑层面上这些动机异常的确切原因知之甚少。其中一个原因是，为什么很少有研究试图调查患者的这些过程，因为直到最近，研究患者大脑动机过程的技术和方法还不发达。最近在（a）MRI脑成像和（B）对奖励和动机处理的基本理解方面取得的进展，意味着现在研究这些过程如何影响精神病和神经病的时机已经成熟。我将研究精神病和帕金森病患者，并检查他们的冷漠和精神病症状在多大程度上与动机和奖励处理系统的异常有关。更多的了解将有助于患者，将使现有的治疗方法得到更好的利用，并有助于开发新的治疗方法。